Fare Guide

Estimated lowest fares found within 7 days

Cheapest Airline Avianca

The cheapest airline(s) flying from Madrid to Santa Cruz de la Sierra is Avianca.

  • Avianca Avianca
  • Air Europa Air Europa
  • LATAM Airlines Group SA LATAM Airlines Group SA
  • Aerolineas Argentinas Aerolineas Argentinas
  • United Airlines United Airlines
Cheapest Month April

Travel Period: February 2025 - January 2026

The cheapest month(s) to fly from Madrid to Santa Cruz de la Sierra is April.

  • Feb 2025
  • Mar 2025
  • Apr 2025
  • May 2025
  • Jun 2025
  • Jul 2025
  • Aug 2025
  • Sep 2025
  • Oct 2025
  • Nov 2025
  • Dec 2025
  • Jan 2026
Cheapest Day of the Week Sunday

The cheapest day(s) of the week to fly from Madrid to Santa Cruz de la Sierra is Sunday.

  • Sun Sunday
  • Mon Monday
  • Tue Tuesday
  • Wed Wednesday
  • Thu Thursday
  • Fri Friday
  • Sat Saturday

Flight Schedules

Last Updated: Thu, 2 Jan, 2025

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    • Earliest
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    • Airline Filter by Airline
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      • Availability
        • M
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        • F
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      • 13:45 MAD
        19:45 VVI
        11Hrs, 00m Direct
      • MADMadrid Barajas Airport 13:45 - VVI 19:45 11h Direct
      • MADMadrid Barajas Airport 13:45
      • VVISanta Cruz Viru Viru International Airport 19:45
      • 11h
      • Direct
      • Boliviana De Aviacion (OB 773)Airbus Industrie A330 200
      • Boliviana De Aviacion (OB 773)
        • M
        • -
        • W
        • -
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        • S
        • -
      • Airbus Industrie A330 200
      • 21:30 MAD
        04:00 VVI
        11Hrs, 30m Direct
      • MADMadrid Barajas Airport 21:30 - VVI 04:00 11h 30m Direct
      • MADMadrid Barajas Airport 21:30
      • VVISanta Cruz Viru Viru International Airport 04:00
      • 11h 30m
      • Direct
      • Boliviana De Aviacion (OB 777)Airbus Industrie A330 200
      • Boliviana De Aviacion (OB 777)
        • -
        • -
        • -
        • -
        • F
        • -
        • S
      • Airbus Industrie A330 200
      • 23:35 MAD
        05:55 VVI
        11Hrs, 20m Direct
      • MADMadrid Barajas Airport 23:35 - VVI 05:55 11h 20m Direct
      • MADMadrid Barajas Airport 23:35
      • VVISanta Cruz Viru Viru International Airport 05:55
      • 11h 20m
      • Direct
      • Air Europa (UX 25)Boeing 787 9
      • Air Europa (UX 25)
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        • -
        • W
        • -
        • -
        • -
        • S
      • Boeing 787 9
      • 23:35 MAD
        05:55 VVI
        11Hrs, 20m Direct
      • MADMadrid Barajas Airport 23:35 - VVI 05:55 11h 20m Direct
      • MADMadrid Barajas Airport 23:35
      • VVISanta Cruz Viru Viru International Airport 05:55
      • 11h 20m
      • Direct
      • Air Europa (UX 25)Boeing 787
      • Air Europa (UX 25)
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      • Boeing 787
      • 13:10 MAD
        04:45 VVI
        20Hrs, 35m 1 Stop (LIM)
      • MADMadrid Barajas Airport 13:10 - VVI 04:45 20h 35m 1 Stop (LIM) Lima
      • MADMadrid Barajas Airport 13:10
        LIMLima Airport 01:00
      • LIMLima Airport 19:10
        VVISanta Cruz Viru Viru International Airport 04:45
      • 20h 35m (5h 50m)
      • 1 Stop LIM · Lima 5h 50m
      • Iberia (IB 125)Airbus A350
        LATAM Airlines Group SA (LA 2406)Airbus
      • Iberia (IB 125)
        • M
        • T
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      • 13:10 MAD
        04:45 VVI
        20Hrs, 35m 1 Stop (LIM)
      • MADMadrid Barajas Airport 13:10 - VVI 04:45 20h 35m 1 Stop (LIM) Lima
      • MADMadrid Barajas Airport 13:10
        LIMLima Airport 01:00
      • LIMLima Airport 19:10
        VVISanta Cruz Viru Viru International Airport 04:45
      • 20h 35m (5h 50m)
      • 1 Stop LIM · Lima 5h 50m
      • Iberia (IB 125)Airbus A359
        LATAM Airlines Group SA (LA 2406)Airbus
      • Iberia (IB 125)
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        • F
        • S
        • S
      • 21:30 MAD
        06:40 VVI
        14Hrs, 10m 1 Stop (CBB)
      • MADMadrid Barajas Airport 21:30 - VVI 06:40 14h 10m 1 Stop (CBB) Cochabamba
      • MADMadrid Barajas Airport 21:30
        CBBCochabamba Airport 05:50
      • CBBCochabamba Airport 04:00
        VVISanta Cruz Viru Viru International Airport 06:40
      • 14h 10m (1h 50m)
      • 1 Stop CBB · Cochabamba 1h 50m
      • Boliviana De Aviacion (OB 779)Airbus Industrie A330 200
        Boliviana De Aviacion (OB 630)Boeing 737 300
      • Boliviana De Aviacion (OB 779)
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      • 21:30 MAD
        07:10 VVI
        14Hrs, 40m 1 Stop (CBB)
      • MADMadrid Barajas Airport 21:30 - VVI 07:10 14h 40m 1 Stop (CBB) Cochabamba
      • MADMadrid Barajas Airport 21:30
        CBBCochabamba Airport 06:20
      • CBBCochabamba Airport 04:00
        VVISanta Cruz Viru Viru International Airport 07:10
      • 14h 40m (2h 20m)
      • 1 Stop CBB · Cochabamba 2h 20m
      • Boliviana De Aviacion (OB 779)Airbus Industrie A330 200
        Boliviana De Aviacion (OB 632)Boeing 737 300
      • Boliviana De Aviacion (OB 779)
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      • 07:25 LPB
        04:00 CBB
        16Hrs, 00m 1 Stop (VVI)
      • LPBLa Paz Airport 07:25 - CBB 04:00 16h 1 Stop (VVI) Santa Cruz de la Sierra
      • LPBLa Paz Airport 07:25
        MADMadrid Barajas Airport 21:30
      • VVISanta Cruz Viru Viru International Airport 08:30
        CBBCochabamba Airport 04:00
      • 16h (2h 40m)
      • 1 Stop VVI · Santa Cruz de la Sierra 2h 40m
      • Boliviana De Aviacion (OB 662)Boeing 737 800
        Boliviana De Aviacion (OB 779)Airbus Industrie A330 200
      • Boliviana De Aviacion (OB 662)
        • -
        • T
        • -
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      No Schedules Sorry, there are no schedules matching your filters. Try removing one. reset
      What’s the fastest flight time from Madrid to Santa Cruz de la Sierra?

      The fastest flight time for direct flights from Madrid to Santa Cruz de la Sierra is 11 hours . Check latest flight schedules & prices on Wego.

      What’s the most popular airline flying from Madrid to Santa Cruz de la Sierra?

      The most popular airline flying from Madrid to Santa Cruz de la Sierra is Air Europa. Find the latest flight deals on Wego.

      How far is Santa Cruz de la Sierra from Madrid?

      The flight distance between Madrid and Santa Cruz de la Sierra is 8919km. Check all available flights on Wego.

      When is the earliest and latest flight of the day?

      The earliest flight of the day departs at 07:25. The last flight of the day departs at 13:10. See the full list of flight times on Wego.

      How many airlines offer direct flights from Madrid to Santa Cruz de la Sierra?

      There are 2 airlines that offer direct flights from Madrid to Santa Cruz de la Sierra. Find out the list of airlines on Wego.

      All Airports in Madrid

      Madrid Barajas Airport MAD

      All Airports in Santa Cruz de la Sierra

      Santa Cruz El Trompillo Airport SRZ

      Santa Cruz Viru Viru International Airport VVI

      Popular Airlines Flying From Madrid to Santa Cruz de la Sierra

      Air Europa ‏()

      Popular Destinations From Santa Cruz de la Sierra

      Popular Destinations From Madrid

      Popular Hotels in Santa Cruz de la Sierra

      Hotels In Popular Destinations